salicylhydroxamic acid

Salicylhydroxamic acid is a small molecule drug that acts as a potent and irreversible inhibitor of the urease enzyme in various bacteria and plants. It is primarily used for urinary tract infections due to its ability to disrupt bacterial metabolism by competitively inhibiting urease, an enzyme essential for certain pathogens. The compound is structurally similar to urea but cannot be hydrolyzed by urease, leading to metabolic disruption in susceptible organisms. Salicylhydroxamic acid also exhibits trypanocidal activity and inhibits alternative oxidase (AOX) in some plants, fungi, and protists. When administered orally, it is metabolized into salicylamide, which has analgesic, antipyretic, and anti-inflammatory properties[1][3][4].

Other names

N,2-dihydroxybenzamide2-hydroxybenzohydroxamic acidsalicylohydroxamic acid