Drug intelligence / Profile preview

salicylic acid + escitalopram

Development stage
Preclinical
Lead developer
Lundbeck
Modality
Small Molecules
Administration
Topical
01

Overview

This is a combination of salicylic acid and escitalopram (abbreviated as ESP). Salicylic acid is a keratolytic agent commonly used topically to treat skin conditions such as acne, psoriasis, warts, and calluses. It works by promoting the shedding of the outer layer of skin and has anti-inflammatory properties. Escitalopram is a selective serotonin reuptake inhibitor (SSRI) primarily used for the treatment of depression and anxiety disorders; it increases serotonin levels in the brain by inhibiting its reuptake into presynaptic cells. There are experimental approaches where ion-pairing strategies combine organic acids like salicylic acid with escitalopram to enhance transdermal delivery of the SSRI[4]. However, this combination does not appear to be an approved or marketed pharmaceutical product but rather an experimental formulation for research on transdermal drug delivery systems[4].

Other names
salicylic acid + ESPsalicylic acid + escitalopram
02

Targets

SERT (Sodium-dependent serotonin transporter)

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