salicylic acid + niacinamide

Salicylic acid + niacinamide is a topical combination therapy investigated for the treatment of chloasma (melasma). Salicylic acid, a beta-hydroxy acid (BHA), acts as a keratolytic agent that promotes the desquamation of the stratum corneum, facilitating the removal of melanin-laden keratinocytes and enhancing the skin's permeability for other active ingredients. Niacinamide (Vitamin B3) complements this action by inhibiting the transfer of melanosomes from melanocytes to keratinocytes and providing anti-inflammatory benefits. Clinical research conducted at Linyi People's Hospital has evaluated this combination's efficacy in reducing Melasma Area and Severity Index (MASI) scores, aiming to provide a synergistic effect that addresses both the removal of existing pigment and the prevention of further melanin deposition while maintaining skin barrier integrity.

Other names

niacinamide + salicylic acidsalicylic acid and niacinamide combination