saline + succinylcholine (South Valley University)

saline + succinylcholine refers to a control arm regimen used in clinical anesthesia research, specifically in a Phase 3 trial (NCT04709315) for rapid sequence induction (RSI). In this regimen, 0.9% normal saline is administered as a placebo pretreatment, followed by the administration of succinylcholine, a depolarizing neuromuscular blocking agent. Succinylcholine acts as a potent agonist at nicotinic acetylcholine receptors at the neuromuscular junction, causing persistent depolarization that leads to rapid and brief skeletal muscle paralysis, facilitating tracheal intubation. This combination is used as a standard-of-care comparator to evaluate the efficacy and safety of alternative induction protocols, such as those involving dexmedetomidine and rocuronium.

Other names

succinylcholinesuxamethoniumsuxamethonium chloride0.9% saline + succinylcholine