saline nasal spray

Saline nasal spray is used as an inert placebo control in clinical research conducted by the Centre for Addiction and Mental Health (CAMH). In the context of study NCT05571878, it serves as the comparator for intranasal insulin (Humalog) to investigate brain insulin resistance in adolescents with major depressive disorder (MDD). The spray consists of a 0.9% sodium chloride solution (saline) and is administered intranasally to establish a baseline for MRI-based neuroimaging assays, which measure changes in brain connectivity, blood flow, and glutamate levels. By comparing the effects of insulin against this saline control, researchers can isolate the specific biological impact of insulin on brain function in depressed youth versus healthy controls.

Other names

0.8 mL intranasal saline