salmeterol

Salmeterol is a long-acting beta-2 adrenergic receptor agonist bronchodilator used primarily for maintenance treatment of asthma and chronic obstructive pulmonary disease. It is a small-molecule inhaled sympathomimetic that produces prolonged relaxation of airway smooth muscle through selective activation of beta-2 adrenergic receptors and increased intracellular cyclic AMP signaling. As a single agent it is marketed as salmeterol xinafoate, and it is also widely used as a component of fixed-dose inhaled combinations such as fluticasone propionate + salmeterol for asthma and COPD maintenance therapy. The provided trial context refers to salmeterol as one component of a generic fluticasone propionate + salmeterol inhalation powder developed by Actavis for asthma, but salmeterol itself is a distinct active ingredient rather than a combination product.

Brand names

Serevent

Other names

salmeterol xinafoate