Drug intelligence / Profile preview

salmeterol + fluticasone + terbutaline

Development stage
Discontinued
Lead developer
GSK
Modality
Small Molecules
Administration
Inhalation
01

Overview

This is a combination drug consisting of three active ingredients: salmeterol, fluticasone, and terbutaline. Salmeterol is a long-acting beta-2 adrenergic receptor agonist (LABA) that relaxes bronchial smooth muscle to improve airflow in the lungs. Fluticasone is an inhaled corticosteroid that reduces inflammation and swelling in the airways. Terbutaline is a short-acting beta-2 adrenergic receptor agonist (SABA) used as a bronchodilator for rapid relief of bronchospasm. While combinations of salmeterol and fluticasone are widely marketed for asthma and COPD management, there are no approved or commonly available pharmaceutical products combining all three agents (salmeterol + fluticasone + terbutaline) into one formulation. Theoretically, such a combination would provide both maintenance therapy (via LABA and corticosteroid) and quick-relief bronchodilation (via SABA), but this triple combination does not appear to be commercially available or clinically standard.

02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)

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