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Salt and water (NaCl) oral rinse is a simple, low-cost intervention evaluated as a non-pharmaceutical treatment for periodontitis, particularly in low-resource settings. In a randomized pilot trial conducted by the **Johns Hopkins Bloomberg School of Public Health** in rural Nepal, the rinse was administered twice daily to pregnant women with periodontitis. The intervention aims to reduce gingival inflammation and oral inflammatory biomarkers by creating an osmotic environment that may help manage bacterial load and soothe inflamed tissues. This saline solution was compared against antiseptic rinses like chlorhexidine and cetylpyridinium chloride to assess its feasibility, acceptability, and clinical impact on periodontal health during pregnancy, with the broader goal of potentially reducing adverse pregnancy outcomes associated with periodontal disease.
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