Drug intelligence / Profile preview

salvia miltiorrhiza

Development stage
Phase 4
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

Salvia miltiorrhiza is a perennial plant in the Lamiaceae family, widely known as Danshen in traditional Chinese medicine. It has been used for centuries to treat cardiovascular and cerebrovascular diseases such as angina pectoris, myocardial infarction, atherosclerosis, thrombosis, and hypertension[3][5][8]. The main active components are water-soluble phenolic acids (e.g., salvianolic acid A and B) and lipophilic diterpenoid tanshinones (e.g., tanshinone IIA)[3][5]. Its mechanisms of action include anti-inflammatory effects, antioxidant activity, inhibition of platelet aggregation (antiplatelet), improvement of microcirculation by promoting blood flow and reducing blood stasis[2][3][5]. Salvia miltiorrhiza extract has shown efficacy in clinical trials for improving cardiovascular biomarkers and symptoms. It is not an approved pharmaceutical drug but is available as an over-the-counter supplement or herbal remedy in many regions[4].

Brand names
danshen
Other names
danshenred sageChinese sagetan shensalvia root
02

Targets

PDIA3 (Membrane-associated rapid response steroid-binding receptor)P2Y12 (Purinergic P2Y12 receptor)PDE2 (Phosphodiesterase 2)SIRT1 (NAD-dependent protein deacetylase sirtuin-1)

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