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salvia officinalis leaf extract
- Development stage
- Unknown
- Lead developer
- Aboca
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Topical
01
Overview
Salvia officinalis leaf extract is a freeze-dried botanical extract derived from the leaves of the sage plant (*Salvia officinalis*). Developed by the Italian company ABOCA, it is being investigated as a natural phytocomplex therapeutic for the management of postoperative pain, often in combination with *Helichrysum italicum* extract. The extract contains a complex mixture of phytochemicals, including rosmarinic acid, flavonoids, and terpenoids, which exhibit anti-inflammatory and analgesic properties. Its mechanism of action likely involves the modulation of inflammatory mediators such as prostaglandins, cytokines, and cyclooxygenase (COX) enzymes. It has been evaluated in Phase 2 clinical trials for its efficacy in reducing pain following surgical procedures.
- Other names
- sage leaf extractSalvia officinalis extract
02
Targets
PTGES (Microsomal prostaglandin E synthase-1)RELA (Nuclear Factor Kappa B Subunit p65)PTPN1 (Protein tyrosine phosphatase 1B)
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