salvia officinalis methanol extract

Salvia officinalis methanol extract is a botanical preparation derived from the common sage plant, traditionally utilized in Mediterranean medicine. Research in diet-induced obese mouse models and 3T3-L1 cell lines demonstrates that the extract possesses significant anti-diabetic, anti-inflammatory, and anti-obesity properties. Its primary mechanism of action involves the activation of peroxisome proliferator-activated receptors (PPARs), which leads to improved insulin sensitivity, reduced blood glucose and insulin levels, and the inhibition of lipogenesis in adipocytes. Additionally, the extract modulates the immune response by decreasing pro-inflammatory cytokines such as TNF-α and IL-12 while increasing anti-inflammatory cytokines like IL-10. These effects suggest its potential as a natural alternative or adjunct to pharmaceutical agents like rosiglitazone for managing metabolic syndrome and associated chronic inflammation.

Other names

sage methanol extractsage MetOH extract