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salvianolic acid B
- Development stage
- Phase 1
- Lead developer
- Nanjing Hongqiao Institute of Pharmaceutical Technology
- Modality
- Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Salvianolic acid B is a water-soluble polyphenolic compound and major active constituent of Salvia miltiorrhiza (Danshen). It has potent antioxidant, anti-inflammatory, cardioprotective, neuroprotective, antineoplastic, hepatoprotective, and metabolism-regulating effects. Its mechanisms are mainly associated with free radical scavenging, anti-inflammatory effects, inhibition of apoptosis and fibrosis, and modulation of various cellular signaling pathways, including suppression of NF-κB and TLR4/NLRP3 inflammasome pathways. Salvianolic acid B has been widely used in traditional Chinese medicine, including as an injectable formulation studied in clinical trials for its safety and pharmacokinetics[1][2][3][4][7].
- Other names
- lithospermic acid Bdanfensuan Bdan shen suan Bsalvianolate b121521-90-2
02
Targets
CASP1 (Caspase-1)TLR4 (Toll-like receptor 4)NLRP3 (Nod-like receptor family pyrin domain-containing protein 3)NF-κB
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