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SAM-02
- Development stage
- Preclinical
- Lead developer
- CNcure
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Intravenous
01
Overview
SAM-02 is a preclinical-stage engineered bacterial therapeutic candidate developed by CNcure. It is part of the company's Salmonella-based Anticancer Modality (SAM) platform, which utilizes attenuated *Salmonella typhimurium* as a delivery vector. These bacteria are engineered to selectively colonize and proliferate within the hypoxic and necrotic regions of solid tumors, which are typically inaccessible to conventional therapies. SAM-02 is designed to deliver a cytolytic anticancer payload directly into the tumor microenvironment, aiming to induce direct tumor cell lysis and trigger a localized immune response against the malignancy while minimizing systemic side effects.
02
Targets
TLR5TLR4 (Toll-like receptor 4)
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