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SAM-04
- Development stage
- Preclinical
- Lead developer
- CNcure
- Modality
- Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Intravenous
01
Overview
SAM-04 is a preclinical-stage multi-payload cancer vaccine developed by CNcure using its proprietary SAM (Stimulator of Antigen-presenting cells and Memory T cells) platform. The therapeutic consists of engineered bacteria designed to deliver multiple immunostimulatory payloads directly to the tumor microenvironment. This approach is intended to activate antigen-presenting cells (APCs) and elicit robust CD4+ and CD8+ T-cell responses against cancer cells. By leveraging the natural tumor-homing abilities of certain bacteria, SAM-04 aims to overcome the immunosuppressive nature of the tumor microenvironment and generate long-lasting anti-tumor immunity.
02
Targets
IL-15R (Interleukin 15 receptor alpha/interleukin 15 complex)TLR5CD4 (T lymphocyte surface antigen)CD8A (CD8 alpha/beta Coreceptor)
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