samarium-153

Samarium-153 is a radioactive isotope utilized in radiopharmaceuticals for targeted radionuclide therapy. It functions as a beta emitter with some gamma emissions, delivering localized radiation to target cells. It is commonly complexed with chelating agents such as ethylenediaminetetramethylene phosphonate (EDTMP) or 1,4,7,10-tetraazacyclododecanetetramethylenephosphonic acid (DOTMP) to specifically target bone metastases, particularly in prostate cancer. Beyond bone-targeted applications, Samarium-153 has also been explored in preclinical and early-stage development for liver malignancies and neuroendocrine tumors, sometimes incorporated into microspheres or conjugated to specific targeting molecules like DOTA-TATE. It can also exhibit radiosensitizing properties, enhancing the effect of other therapies.

Brand names

Quadramet

Other names

Samarium-153-DOTMPSamarium153-DOTMPSamarium 153-DOTMPSm-153-DOTMPSm153-DOTMPSm 153-DOTMP153Sm-DOTMPSamarium-153-EDTMPSamarium153-EDTMPSamarium 153-EDTMP153Sm-EDTMPSamarium-153-ethylene diamine tetramethylene phosphonateSamarium153-ethylene diamine tetramethylene phosphonateSamarium 153-ethylene diamine tetramethylene phosphonate153Sm-1,4,7,10tetraazacyclododecanetetramethylenephosponic acid