san-huang-xie-xin-tang

San-Huang-Xie-Xin-Tang is a traditional Chinese medicine (TCM) formula used for centuries for gastrointestinal and inflammatory disorders, including gastritis, gastric bleeding, peptic ulcers, atherosclerosis, upper respiratory tract infection, diabetic nephropathy, and more[1][2][7]. The formula comprises three herbs: Coptidis rhizoma (Coptis chinensis), Rhei rhizoma (Rheum palmatum or Rheum officinale), and Scutellariae radix (Scutellaria baicalensis)[1][2][3][4][5]. Its mechanism is largely anti-inflammatory and immunomodulatory, related to suppression of cytokine/chemokine production, inhibition of the NF-κB pathway, and reduction of MAPK signaling. It also possesses anti-oxidant, anti-hypertensive, neuroprotective, and anti-apoptotic effects[1][2][7]. Active constituents include berberine, baicalin, emodin, rhein, aloe-emodin, and baicalein[2].

Brand names

TCM Zone Coptis Scute and Rhubarb FormulaKamwo Three Yellow Combination

Other names

SHXXTCoptis and Rhubarb CombinationCoptis Scute and Rhubarb FormulaThree Yellow CombinationXie Xin TangSan'o-shashin-toYellow Purge the Heart DecoctionDecoction to Purge Heat from the Heart and Stomach