Drug intelligence / Profile preview

Sandoglobulin NF Liquid

Development stage
Unknown
Lead developer
CSL Behring
Modality
Antibody-Based Therapeutics
Administration
Intravenous
01

Overview

Sandoglobulin NF Liquid (also known as Redimune NF Liquid) is a high-concentration, 12% (120 g/L) liquid formulation of intravenous immunoglobulin (IVIG) developed by CSL Behring (formerly ZLB Behring). It is composed of human IgG antibodies purified from large pools of human plasma, providing a diverse repertoire of antigen-binding specificities. This "New Formulation" (NF) is a ready-to-use solution stabilized with L-proline, L-isoleucine, and nicotinamide, notably excluding sucrose to minimize the risk of renal complications such as osmotic nephrosis. It was primarily indicated for the treatment of primary and secondary immune deficiencies and immune thrombocytopenic purpura (ITP). Although approved by Health Canada in 2006, the product was discontinued from the market in 2010.

Brand names
Sandoglobulin NF LiquidRedimune NF Liquid
Other names
immune globulin intravenous (human)IVIGIGIV
02

Targets

FCGR3B (Fc gamma receptor III)FcγR (Low affinity immunoglobulin gamma Fc region receptor II-c)

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