sanglifehrin a

Sanglifehrin A is a natural product and experimental immunosuppressive agent belonging to the class of cyclic peptides. It was originally isolated from Streptomyces sp. and is structurally distinct from cyclosporin A. Sanglifehrin A binds with high affinity to cyclophilin A but does not inhibit calcineurin, indicating a novel mechanism of action among immunophilin-binding drugs. Its primary pharmacological effect is potent inhibition of T cell proliferation induced by interleukin-2 (IL-2), acting at the G1 phase of the cell cycle without affecting IL-2 receptor expression or calcium-dependent IL-2 production. Additionally, it uniquely modulates dendritic cell differentiation and function by reducing macropinocytosis and lectin-mediated endocytosis through downregulation of C-type lectins such as DC-SIGN and mannose receptor, while increasing FcαRI (CD89) and FcγRII (CD32). Sanglifehrin A also potently inhibits bioactive IL-12p70 production in human dendritic cells via a cyclophilin-independent mechanism[3][4][5][6][7]. The compound has been explored for its immunosuppressive properties but has not reached clinical approval.

Other names

Sanglifehrin ASFA