Drug intelligence / Profile preview

sanguisorba officinalis ethanol extract

Development stage
Preclinical
Modality
Small Molecules
Administration
Topical, Oral
01

Overview

Sanguisorba officinalis ethanol extract is a plant-derived research compound obtained from the roots or aerial parts of *Sanguisorba officinalis* L., commonly known as great burnet. This extract contains a complex mixture of bioactive secondary metabolites, including triterpene glycosides, phenolic acids (such as gallic and chlorogenic acids), tannins, flavonoids, and saponins. In preclinical studies, it has demonstrated multi-target biological activities, including anti-inflammatory effects via suppression of NF-κB and AP-1 signaling, antibacterial activity against MRSA, and antioxidant properties. Research in hepatocellular carcinoma (HCC) models suggests it inhibits cell proliferation and induces apoptosis by modulating the EGFR, PI3K/AKT, and MAPK pathways. It is primarily utilized in academic research for potential applications in inflammatory skin diseases, colitis, and oncology.

Other names
Sanguisorba officinalis extractgreat burnet extractSO extract
02

Targets

MEKNF-κBFOS (Activator Protein 1)

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