Drug intelligence / Profile preview

Sanhuang Ointment

Development stage
Unknown
Lead developer
Traditional Chinese Medicine Hospital of Hangzhou
Administration
Topical
01

Overview

Sanhuang Ointment, also known as Sanhuang Gao (三黄膏), is a traditional Chinese medicine preparation used topically for its anti-inflammatory, analgesic, and antimicrobial properties. Its name, meaning 'three yellows,' refers to its primary herbal ingredients: Coptidis Rhizoma (Huang Lian, 黄连), Scutellariae Radix (Huang Qin, 黄芩), and Phellodendri Chinensis Cortex (Huang Bai, 黄柏). [2, 4, 7] Some formulations may also include other herbs like Gardenia Fructus (Zhi Zi, 栀子). [2, 3, 7] The ointment is traditionally used for conditions characterized by heat, swelling, and pain, such as early-stage boils and sores, mild burns, traumatic injuries, and hemorrhoids. [2, 5, 7, 12] Research indicates that its mechanism of action involves multiple pathways, including the inhibition of the IL-17/NF-κB signaling pathway to reduce inflammation, particularly in the context of bacterial infections like MRSA. [4, 8] It has also been shown to regulate pain-related genes and vascular growth factors to alleviate hemorrhoid symptoms. [12]

Brand names
San Huang GaoHerbal Ice Poultice
Other names
三黄软膏Sanhuang Gao三黄膏
02

Targets

IL-6 (Interleukin 6)VEGFA (Vascular endothelial growth factor A)CGRP (Calcitonin gene-related peptide)NF-κBIL-17A (Interleukin-17A)IL1B (Interleukin-1 beta)TNFA (Tumor necrosis factor alpha (soluble))SP (Substance P)TRPV1 (Transient receptor potential cation channel subfamily V member 1)

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