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Sanjie Prescription

Development stage
Preclinical
Lead developer
Lianyungang Kanion
Modality
Implantable Devices → Device-based Delivery → Drug Delivery Systems, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Inhalation Devices → Device-based Delivery → Drug Delivery Systems
Administration
Oral
01

Overview

Sanjie Prescription is a traditional Chinese medicine (TCM) herbal formula used primarily in China. It is not a single pharmaceutical compound but rather a multi-herb prescription, with variations in composition depending on the specific clinical indication and practitioner. The formula is most commonly referenced for its use in treating phlegm stagnation syndromes such as hyperthyroidism and certain tumors or nodules. One documented version of the Xiaoying Sanjie prescription includes Bupleurum (10 g), Radix paeoniae alba (10 g), Fructus aurantii (10 g), Pinellia ternata (10 g), Ginger magnolia (6 g), Poria (15 g), Prunella vulgaris (10 g), Radix scrophulariae (10 g), Zhejiang Fritillaria (10 g), Forsythia suspensa fruit (10 g), Albizia flower (10 g), Salvia miltiorrhiza root and rhizome (10g), Perilla leaf (6g) and Licorice root and rhizome(5g)[6]. The mechanism of action is based on TCM theory—resolving phlegm, softening hard masses, dispersing nodules, clearing heat, detoxifying, promoting blood circulation and relieving depression[6]. There are also references to "Tangcancer-Sanjie" prescriptions being used adjunctively with targeted therapies for non-small cell lung cancer[8][10], though exact compositions may vary.

Other names
Sanjie FangXiaoying Sanjie prescriptionTangcancer-Sanjie prescription
02

Targets

PAI-1 (Plasminogen activator inhibitor type 1)SPHK1 (Sphingosine kinase 1)

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