Santacruzamate A

Santacruzamate A is a cytotoxin derived from the Panamanian marine cyanobacterium cf. Symploca sp. It functions as a potent and selective small molecule inhibitor of histone deacetylase 2 (HDAC2), exhibiting picomolar inhibitory concentrations (IC50 of 112-119 pM). It also demonstrates inhibitory activity against HDAC6 in the nanomolar range (IC50 = 433 nM), with significantly lower activity against HDAC4. Its mechanism of action involves the inhibition of HDACs, which leads to cell cycle arrest and apoptosis, particularly in various cancer cell lines such as HuT-78 cutaneous T-cell lymphoma cells. Beyond its anticancer potential, Santacruzamate A has also shown neuroprotective effects against amyloid-β protein fragment 25–35-induced toxicity, suggesting its relevance in neurological disease research.

Other names

Ethyl N-[4-oxo-4-[(2-phenylethyl)amino]butyl]carbamate