Drug intelligence / Profile preview

SAP-021-T2

Development stage: Unknown
Lead developer: Avata Biosciences
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

SAP-021-T2 is a novel, solid oral dosage form (capsule) of cannabidiol (CBD) developed by Sapient Therapeutics (Australia) PTY Ltd. It is one of two formulation variants (alongside SAP-021-T1) designed to provide a more convenient and potentially more bioavailable alternative to the existing oil-based oral solution, Epidiolex. The drug is being developed via the FDA's 505(b)(2) regulatory pathway for the treatment of seizure disorders associated with Dravet syndrome and other related epilepsy conditions. In Phase 1 clinical trials, SAP-021-T2 was evaluated in healthy volunteers to compare its relative bioavailability and food-effect profile against the reference product, Epidiolex.

Other names: SAP-021-T2SAP021-T2SAP 021-T2

Targets

CNR1 (Cannabinoid receptor 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)ENT1 (Solute carrier family 29 member 1)GPR55 (G protein-coupled receptor 55)

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