saposhnikovia divaricata extract

Saposhnikovia divaricata extract is a botanical product derived from the roots of the *Saposhnikovia divaricata* plant, a staple in traditional Chinese medicine known as Fangfeng. It possesses significant anti-inflammatory, antioxidant, and analgesic properties. Recent research indicates its potential in treating ulcerative colitis by inhibiting ferroptosis—a form of regulated cell death—through the modulation of the p53/SLC7A11/GPX4 signaling axis. Specifically, the extract down-regulates p53 expression while up-regulating the cystine/glutamate transporter (SLC7A11) and glutathione peroxidase 4 (GPX4), leading to reduced oxidative stress and proinflammatory cytokine levels.

Other names

FangfengRadix SaposhnikoviaeLedebouriella divaricata extractSiler divaricatum extract