Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
saposhnikoviae radix-derived extracellular vesicles
- Development stage
- Preclinical
- Lead developer
- Xi'an Jiaotong University
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Oral
01
Overview
Saposhnikoviae radix-derived extracellular vesicles (SR-EVs) are plant-derived extracellular vesicles isolated from *Saposhnikovia divaricata* (Saposhnikoviae Radix), a traditional Chinese herb [Su1509]. Developed by researchers at Xi'an Jiaotong University, these nanotherapeutic vesicles exhibit high gastrointestinal stability and colonic retention. In preclinical models of ulcerative colitis, SR-EVs demonstrate potent antioxidant and anti-inflammatory properties by scavenging reactive oxygen species, suppressing M1 macrophage polarization, and downregulating pro-inflammatory cytokines [Su1509]. Furthermore, they facilitate intestinal epithelial repair and restore physical, chemical, immune, and biological barriers by inhibiting the PI3K/Akt signaling pathway [Su1509].
- Other names
- SR-derived extracellular vesiclesSaposhnikoviae Radix-derived extracellular vesicles
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)PI3K (Phosphoinositide-3-kinase regulatory subunit 6)
Beyond the preview
Go deeper on saposhnikoviae radix-derived extracellular vesicles.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on saposhnikoviae radix-derived extracellular vesicles.