SAR442357

SAR442357 is a **novel nonabsorbed, gut-restricted polymeric phosphate and bile acid sequestrant** developed for therapeutic use, notably for diabetic kidney disease and related metabolic and cardiovascular complications. By binding bile acids and dietary phosphate in the intestine, SAR442357 interrupts the enterohepatic cycle of bile acids, lowers serum cholesterol, regulates glucose, and slows the progression of diabetic nephropathy. Preclinical studies have shown that SAR442357 provides combined metabolic benefits—including improved glycemic control, reduced cholesterol, and kidney protection—superior to standard bile acid sequestrants and angiotensin II receptor blockers in diabetic animal models[1][3].