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Saraswatarishta
- Development stage
- Phase 3
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Saraswatarishta is a traditional Ayurvedic polyherbal fermented liquid formulation, classified as an 'Arishta,' which contains self-generated alcohol that acts as a preservative and a delivery vehicle for active herbal constituents. It is primarily used as a 'Medhya Rasayana' (nootropic or brain tonic) to enhance memory, concentration, and cognitive function. The formulation typically consists of approximately 18 herbal ingredients, including *Bacopa monnieri* (Brahmi), *Asparagus racemosus* (Shatavari), and *Terminalia chebula* (Haritaki). It is indicated for various neurological and psychological conditions, including Alzheimer's disease, Huntington's disease, depression, and anxiety. Some variants, known as Saraswatarishta with Gold, incorporate *Swarna Bhasma* (calcined gold) to enhance therapeutic efficacy in severe neurodegenerative cases. Research suggests it may work by reducing toxic protein aggregates, such as amyloid-beta plaques and polyglutamine (polyQ) repeats, and by modulating neurotransmitter activity.
- Brand names
- SaraswatarishtaSaraswatarishtamSaraswatarishta with GoldSaraswatarishta Gold
- Other names
- SaraswatharishtamSaraswatarishta
02
Targets
ALOX5 (Arachidonate 5-lipoxygenase)Amyloid-beta aggregate (N-terminal epitope)CASP8 (Caspase-8)GSK3 (Glycogen synthase kinase 3 beta)PRKCD (Protein kinase C delta)PolyQ aggregate (Polyglutamine aggregate)NHE1 (Sodium/hydrogen exchanger 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)Aβ (Amyloid-beta peptides and aggregates)
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