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sarcobatus vermiculatus pollen
- Development stage
- Unknown
- Lead developer
- Jubilant HollisterStier
- Modality
- Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intradermal, Subcutaneous, Percutaneous
01
Overview
Sarcobatus vermiculatus pollen extract, derived from the greasewood plant, is a biologic product used for the diagnosis and treatment of Type I hypersensitivity reactions. As a diagnostic tool, it is employed in percutaneous (skin prick) or intradermal testing to confirm sensitization to greasewood pollen. As a therapeutic agent, it is used in allergen immunotherapy (AIT), where escalating doses are administered subcutaneously to induce clinical tolerance. The mechanism of action involves a complex modulation of the immune system, including the induction of regulatory T cells (Tregs), a shift from Th2 to Th1 cytokine production, and the production of "blocking" antibodies such as IgG4, which compete with IgE for allergen binding on mast cells and basophils.
- Other names
- Greasewood pollen extractSarcobatus vermiculatus extract
02
Targets
A. annua-specific IgE (Artemisia annua-specific immunoglobulin E)
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