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sarcophine-diol
- Development stage
- Preclinical
- Lead developer
- South Dakota State University
- Modality
- Small Molecules
- Administration
- Topical, Oral
01
Overview
Sarcophine-diol (SD) is a semi-synthetic derivative of sarcophine, a marine natural product isolated from the soft coral *Sarcophyton glaucum*. It is being investigated for its chemopreventive and therapeutic potential against melanoma and non-melanoma skin cancers. SD acts by inducing G0 phase cell cycle arrest and triggering apoptosis through both intrinsic and extrinsic pathways. Its molecular mechanism involves the downregulation of Cyclooxygenase-2 (COX-2), Signal Transducer and Activator of Transcription 3 (STAT-3), and Cyclin D1, alongside the upregulation of the tumor suppressor p53 and the activation of caspases 3, 8, and 9. Additionally, SD disrupts cell division by interfering with the formation of the contractile ring and inhibiting phospholipase A2 (PLA2) and phospholipase C (PLC) activities, which leads to decreased membrane permeability and subsequent cell death.
- Other names
- sarcophine diol
02
Targets
PTGS2 (Prostaglandin-Endoperoxide Synthase 2)CASP3 (Caspase-3)PLA2 (Phospholipase A2 group IID)CCND1 (Cyclin D1)CASP9 (Caspase-9)TP53 (Cellular Tumor Antigen p53 R175H)CASP8 (Caspase-8)STAT3 (Signal Transducer and Activator of Transcription 3)PLC (Phospholipase C family)
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