Drug intelligence / Profile preview

Sarocladium strictum ethyl acetate extract

Development stage
Preclinical
Lead developer
Florida International University
01

Overview

Sarocladium strictum ethyl acetate extract is a fungal extract derived from the secondary metabolites of the endophytic fungus Sarocladium strictum. It is currently being investigated for its potential as a malaria transmission-blocking agent [1.1]. In preclinical evaluations, the extract demonstrated the ability to completely block the transmission of the malaria parasite Plasmodium falciparum to Anopheles gambiae mosquitoes in standard membrane feeding assays (SMFA) [1.1]. Active fractions of the extract have been shown to significantly reduce the number of oocysts in mosquitoes, serving as a starting point for isolating and identifying potent antimalarial lead compounds [1.1].

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