Drug intelligence / Profile preview

sarracenia purpurea extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Sarracenia purpurea extract is a botanical preparation derived from the purple pitcher plant, Sarracenia purpurea, native to North America. It has a long history of traditional use, particularly among indigenous communities, for the management of symptoms associated with diabetes, pain, and viral infections. The leaf extract has demonstrated cytoprotective and anti-diabetic activity in vitro, chiefly mediated by active constituents such as hyperoside (quercetin-3-O-galactoside) and morroniside, which may protect cells from glucose toxicity and diabetic neuropathy. The root extract is used in topical pain relief preparations (e.g., Sarapin) and has shown potential antioxidant, anticancer, and antibacterial properties, notably inhibiting targets like human dihydroorotase. Sarracenia purpurea extracts display antiviral properties against herpes simplex virus type 1 (HSV-1) and poxvirus, through dual mechanisms: direct inhibition of virus attachment/entry and inhibition of viral gene expression. The complete spectrum of active compounds remains unidentified, and further studies are required to confirm the clinical efficacy and precise mechanisms.

Other names
Sarracenia purpurea leaf extractSarracenia purpurea root extractpurple pitcher plant extract
02

Targets

vRNAP (Poxvirus early gene transcription machinery (vRNAP complex))AGEs (Advanced glycation end-products)

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