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Drug intelligence / Profile preview
sars-cov-2 prefusion spike delta TM recombinant protein vaccine with AF03 adjuvant
- Development stage
- Unknown
- Lead developer
- Parent
- Modality
- Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
- Administration
- Intramuscular
01
Overview
CoV2 preS dTM-AF03 is a recombinant protein-based vaccine candidate developed for the prevention of COVID-19. It consists of a stabilized prefusion form of the SARS-CoV-2 spike (S) protein, produced using a baculovirus expression system in insect cells, and is formulated with the AF03 oil-in-water squalene-based adjuvant to enhance immune response. The primary mechanism is immunostimulation via induction of neutralizing antibodies against the SARS-CoV-2 S protein. The vaccine was developed by Sanofi Pasteur and has been evaluated in clinical trials for safety and immunogenicity as both primary vaccination and booster in adults[1][3][6].
- Other names
- SARS-CoV-2 prefusion spike delta TM (CoV2 preS dTM) with AF03 adjuvantsars-cov-2 pres dtm (booster only) vaccine, recombinant
02
Targets
ACE2 (Angiotensin-converting enzyme 2)SARS-CoV-2 spike
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