Drug intelligence / Profile preview

SART2 peptides

Development stage
Unknown
Lead developer
Kurume University
Modality
Peptides, Vaccines & Immunotherapeutics
Administration
Subcutaneous
01

Overview

SART2 peptides are immunogenic components derived from the SART2 (Squamous cell carcinoma Antigen Recognized by T cells 2) protein, which serves as a tumor-rejection antigen. These peptides, specifically HLA-A24-restricted nonapeptides, are designed to function as a cancer vaccine by stimulating the immune system to produce antigen-specific cytotoxic T lymphocytes (CTLs). These CTLs are capable of recognizing SART2 epitopes presented on the surface of malignant cells, leading to targeted tumor cell destruction. SART2 is frequently overexpressed in various cancers, including squamous cell carcinomas and gynecologic malignancies such as ovarian, cervical, and endometrial cancers. These peptides are often utilized as key components in multi-epitope vaccine candidates, such as TAS0314, to provide a broader and more robust anti-tumor immune response.

Other names
SART-2 peptidesSART2 peptidesSART 2 peptidesSART2-derived peptidesSART-2-derived peptidesSART 2-derived peptidesSART2 antigen-derived peptidesSART-2 antigen-derived peptidesSART 2 antigen-derived peptides
02

Targets

HLA-A*02 (Human leukocyte antigen A*02 complexed peptide)HLA-A*24 (Major histocompatibility complex class I molecule presenting MAGE-A4 peptide)SCCA (Serpin family B member 4)

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