Drug intelligence / Profile preview

SASPject PT3

Development stage
Unknown
Lead developer
SASPiPhi
Modality
Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics
Administration
Intravenous
01

Overview

**SASPject PT3** is an investigational intravenous antibacterial agent developed by Phico Therapeutics using the proprietary SASPject platform, which employs engineered bacteriophages to deliver a gene encoding small acid-soluble spore proteins (SASPs) specifically into *Pseudomonas aeruginosa* bacteria. The SASPs bind to and inactivate bacterial DNA regardless of sequence, preventing metabolism and reproduction while minimizing resistance development and sparing non-target bacteria. It targets serious hospital-acquired infections such as ventilator-associated pneumonia, urinary tract infections, bloodstream infections, and wound infections caused by multidrug-resistant *P. aeruginosa*, a WHO priority pathogen.[1][3][7]

Other names
SASPject PT3
02

Targets

Neuraminidase

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