saxagliptin

Saxagliptin is an oral antidiabetic drug belonging to the dipeptidyl peptidase-4 (DPP-4) inhibitor class. It is used in combination with diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Saxagliptin works by inhibiting the DPP-4 enzyme, which increases levels of incretin hormones. These hormones stimulate insulin release from pancreatic beta cells and decrease glucagon secretion from alpha cells in the pancreas, leading to reduced blood glucose levels after meals and decreased hepatic glucose production. Saxagliptin does not cause weight gain or significant hypoglycemia when used alone and is not indicated for type 1 diabetes or diabetic ketoacidosis[1][2][3][4][5].

Brand names

OnglyzaKombiglyze XRQternQternmet XR

Other names

(1S,3S,5S)-2-{(2S)-2-amino-2-[(1R,3S,5R,7S)-3-hydroxytricyclo[3.3.1.1~3,7~]dec-1-yl]acetyl}-2-azabicyclo[3.1.0]hexane-3-carbonitrile(1S,3S,5S)-2-[(2R)-2-amino-2-(3-hydroxyadamantan-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrileCHEMBL3114067CHEMBL-3114067CHEMBL 3114067EN300-27122458EN-300-27122458EN 300-271224581564265-93-5