SB 242084

SB 242084 is a selective, brain-penetrant, and potent antagonist of the **serotonin 5-HT2C receptor**. It is primarily a research tool compound, not approved for clinical use, and was developed as a potential medication for anxiety disorders and other neuropsychiatric indications. In animal models, SB 242084 exhibits anxiolytic-like effects, enhances dopamine signaling in specific brain regions, and produces mild stimulant-like and reinforcing effects, but its stimulant properties are significantly weaker than amphetamines or cocaine. It significantly potentiates the effects of selective serotonin reuptake inhibitors (SSRIs), including their anxiolytic and antidepressant effects, and may reduce certain SSRI-related side effects. SB 242084 demonstrates over 100-fold selectivity for the 5-HT2C receptor over the related 5-HT2B and 5-HT2A receptors, and minimal activity at other serotonergic, dopaminergic, or adrenergic receptors. While some preclinical data suggested utility in depression and obsessive-compulsive disorder, there is no evidence of clinical development or approval. SB 242084 is widely used in neuropharmacological research for understanding serotonergic signaling and the role of 5-HT2C antagonism in behavior and neurochemistry[1][4][7][10].

Other names

SB-242,084SB242084SB-242084SB 242084