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SB03178
- Development stage
- Unknown
- Lead developer
- BC Cancer Research Institute
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics
01
Overview
SB03178: sourced facts only. name: "natGa-labeled complexes displayed dose-dependent FAP inhibition, with binding potency of natGa-SB03178 being ∼17 times higher than natGa-SB04033." [PMID:38367492]; target: "natGa-labeled complexes displayed dose-dependent FAP inhibition, with binding potency of natGa-SB03178 being ∼17 times higher than natGa-SB04033." [PMID:38367492]; developer: "Department of Molecular Oncology, BC Cancer Research Institute, Vancouver, BC, V5Z1L3, Canada." [PMID:38367492]; modality: "Development, preclinical evaluation and preliminary dosimetry profiling of SB03178, a first-of-its-kind benzo[h]quinoline-based fibroblast activation protein-α-targeted radiotheranostic for cancer imaging and therapy." [PMID:38367492]; stage: "[177Lu]Lu-SB03178 exhibited a combination of high and sustained tumor uptake, with excellent tumor-to-critical organ uptake ratios resulting in a high radiation absorbed dose to the tumor and a low estimated whole-body dose to humans." [PMID:38367492]
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