SC-560

SC-560 is a **synthetic small molecule** in the pyrazole class, acting as a highly selective inhibitor of cyclooxygenase-1 (**COX-1**), with an IC50 of 9 nM for COX-1 and a much lower affinity for COX-2 (IC50 of 6.3 µM)[1][2][3]. It is used primarily in biochemical and pharmaceutical research to study COX-1 function, prostaglandin signaling, inflammation, and angiogenesis[1][5]. SC-560 demonstrates anti-inflammatory, antitumor, and antiviral activity and also plays roles as an apoptosis inducer and modulator of angiogenesis[2][5]. The compound has been explored for experimental therapy in neuroinflammation, cancer, and endothelial dysfunction[1][3]. Its oral bioavailability is extremely low due to poor water solubility[3]. SC-560 was developed as part of research efforts that led to COX-2 inhibitors like celecoxib[3].

Brand names

SC-560SC560SC 560

Other names

5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazoleSC-560 Assay ReagentSC560 Assay ReagentSC 560 Assay ReagentSC-560, COX-1 inhibitorCyclooxygenase, SC 560, inhibit, Inhibitor, SC-560, COX