SC-62-1

SC-62-1 is a small molecule quinolinol derivative and a potent inducer of p53-independent apoptosis, developed as an optimized analog of MMRi62. Originally identified through a screen for inhibitors of the MDM2-MDM4 E3 ligase complex, SC-62-1 promotes the degradation of MDM4. However, chemical proteomics studies reveal that SC-62-1 acts as a multi-targeting covalent inhibitor, binding to over 1,500 cellular proteins. This broad reactivity significantly alters multiple metabolic and stress response pathways, including carbon metabolism, RNA metabolism, amino acid metabolism, and translation. SC-62-1 has demonstrated potent efficacy in eliminating melanoma cells, including those that have acquired resistance to BRAF inhibitors, suggesting its potential for overcoming drug resistance in solid tumors.