SCH 50911

SCH 50911 is a **selective, competitive, orally-active γ-aminobutyric acid type B (GABA-B) receptor antagonist**. Structurally, it is a novel morpholino-acetic acid derivative developed for research use. SCH 50911 exhibits potent inhibition of GABA binding at the GABA-B receptor, with low micromolar affinity, and shows high selectivity over GABA-A and other central neurotransmitter receptors. In animal studies, it has been used to study GABAergic transmission, absence seizures, and withdrawal syndromes, including for γ-hydroxybutyrate (GHB). Its main application is in pharmacological research, especially neuroscience, epilepsy, and addiction[1][6][7][8][4].

Other names

(S)-2-(5,5-dimethylmorpholin-2-yl)acetic acid(+)-(S)-5,5-dimethylmorpholinyl-2-acetic acid2-[(2S)-5,5-dimethylmorpholin-2-yl]acetic acidSCH 50911 free baseSCH50911 free baseSCH-50911 free baseSCH 50911 (hydrochloride)