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schinus terebinthifolius raddi
- Development stage
- Unknown
- Lead developer
- Hebron
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Vaginal
01
Overview
Schinus terebinthifolius Raddi (commonly known as 'aroeira' or Brazilian pepper tree) is a plant-derived botanical extract formulated as an intravaginal gel (7.4% concentration) for the treatment of bacterial vaginosis, cervicitis, and vaginitis. Developed and manufactured by Hebron Laboratory (Laboratório Hebron) in Brazil, the gel is marketed under the brand name Kronel. Its therapeutic efficacy is attributed to the complex phytochemical composition of the aroeira extract, which exhibits broad-spectrum antimicrobial, anti-inflammatory, and wound-healing properties against polymicrobial vaginal flora, including *Gardnerella vaginalis* and *Candida* species. Clinical trials, including those conducted in collaboration with the Institute for Maternal/Infant Health (IMIP) in Brazil, have evaluated its efficacy and safety compared to standard therapies like metronidazole gel.
- Brand names
- Kronel
- Other names
- aroeiraaroeira da praiaBrazilian pepper tree extractSchinus terebinthifolius Raddi extractSchinus terebinthifolius extract
02
Targets
NeuraminidasePLA2 (Phospholipase A2 group IID)HRH1 (Histamine H1 Receptor)PB2cap (Influenza virus polymerase basic protein 2 (PB2) cap-binding domain)XO (Xanthine Oxidoreductase)
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