Drug intelligence / Profile preview

Schisandrol A

Development stage
Unknown
Lead developer
Peking University
Modality
Small Molecules
01

Overview

Schisandrol A: sourced facts only. name: "Moreover, SolA allosterically mediated ATP6V0D1 conformation via targeting a unique cysteine 335 residue to activate V-ATPase-dependent lysosomal acidification." [PMID:36213534]; target: "Moreover, SolA allosterically mediated ATP6V0D1 conformation via targeting a unique cysteine 335 residue to activate V-ATPase-dependent lysosomal acidification." [PMID:36213534]; developer: "State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China." [PMID:36213534]; modality: "In this study, we discovered a natural small-molecule schisandrol A (SolA) with significant protective effect against AGEs-induced neuronal cell apoptosis." [PMID:36213534]; stage: "In this study, we discovered a natural small-molecule schisandrol A (SolA) with significant protective effect against AGEs-induced neuronal cell apoptosis." [PMID:36213534]

02

Targets

V-ATPase (Vacuolar-type H+-ATPase)

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