schisanhenol

Schisanhenol is a natural biphenylcyclooctene-type lignan compound isolated from several Schisandra species, most notably Schisandra chinensis and Schisandra rubriflora[1][4][8][13]. It is being investigated for its **anti-inflammatory**, **antioxidant**, **neuroprotective**, and **hepatoprotective** properties. Mechanistically, schisanhenol inhibits the nuclear factor-kappa B (NF-κB) signaling pathway, suppressing inflammatory cytokine production including TNF-α, IL-6, and IL-1β in both cellular and animal models[1][3][7][12]. It activates SIRT1-PGC-1α signaling and inhibits phosphorylation of Tau, thus demonstrating **potential benefit in cognitive disorders such as Alzheimer's disease**[4]. In models of non-alcoholic fatty liver disease (NAFLD), schisanhenol downregulates miR-802, thereby activating the AMPK pathway and improving hepatic steatosis[10]. It shows promise as a candidate for treating conditions involving cytokine storm, NAFLD, and neurodegeneration. Additionally, it has reported central inhibitory and anticonvulsant actions, making it of potential interest in neurological indications[2][4]. Schisanhenol is commonly used as a research compound in preclinical models, but is not currently approved as a pharmaceutical.

Other names

Gomisin K3Schisanhenol-RMSchisanhenol (Schizanhenol)Schisanhenol/(+)-Gomisin K3Schisandra chinensis phenol(+)-Gomisin K369363-14-0