Schmallenberg virus Gc subunit vaccine

A **veterinary recombinant protein subunit vaccine candidate** directed against **Schmallenberg virus**, built around the viral envelope glycoprotein **Gc**, particularly the immunogenic amino-terminal head or head-stalk region that contains major neutralizing epitopes. It was developed in preclinical research programs including groups at the Friedrich-Loeffler-Institut and collaborators as a **DIVA-compatible** alternative to whole-virus vaccines for preventing Schmallenberg virus infection and associated reproductive disease in ruminants such as cattle and sheep. The intended mechanism is induction of neutralizing anti-Gc antibodies that block viral entry and infection; published studies showed that some Gc-domain constructs could protect experimental animals, while other baculovirus-expressed Gc subunit formulations in cattle were immunogenic but did not reliably prevent viremia after challenge.

Other names

SBV Gc subunit vaccineSchmallenberg virus envelope glycoprotein Gc subunit vaccineGc AminoSchmallenberg virus Gc amino-terminal domain subunit vaccine