SCN9A shRNA

SCN9A shRNA is a research-stage gene-silencing tool designed to knock down the expression of the SCN9A gene, which encodes the voltage-gated sodium channel subunit Nav1.7 (also known as PN1 or NE-NA). Nav1.7 is a critical mediator of pain signaling in the peripheral nervous system, and its dysregulation is linked to various pain disorders and certain cancers. The tool utilizes short hairpin RNA (shRNA) delivered via viral vectors (e.g., lentivirus, AAV) or plasmids to induce RNA interference (RNAi). In preclinical studies, SCN9A shRNA has been investigated for its potential to attenuate inflammatory and neuropathic pain, as well as for its role in inhibiting tumor progression and connectivity in glioblastoma models. It is primarily available as a laboratory reagent from life science suppliers and is not currently a branded therapeutic candidate.

Other names

Nav1.7 shRNANav-1.7 shRNANav 1.7 shRNASCN9A short hairpin RNASCN-9A short hairpin RNASCN 9A short hairpin RNA