scoparone

Scoparone (6,7-dimethoxycoumarin) is a natural bioactive coumarin derivative primarily isolated from the stems and leaves of *Artemisia capillaris*. It exhibits a broad spectrum of pharmacological activities, including anti-inflammatory, anti-oxidant, anti-tumor, lipid-lowering, and anti-coagulant effects. In oncology research, particularly concerning breast cancer, scoparone has been shown to inhibit cell viability and migration while promoting apoptosis. Its mechanism of action involves the suppression of the NF-κB signaling pathway, which is achieved through the regulation of the SNHG12/miR-140-3p/TRAF2 axis. Specifically, scoparone inhibits the expression of the long non-coding RNA SNHG12, leading to the upregulation of miR-140-3p and the subsequent downregulation of TRAF2. Historically, scoparone has also been recognized for its hypotensive and cholagogic (bile-promoting) properties.

Other names

6,7-dimethoxycoumarinesculetin dimethyl ether6,7-dimethoxy-2H-chromen-2-one6,7-dimethoxychromen-2-one