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SCR-9140

Development stage: Preclinical
Lead developer: Simcere Pharmaceutical Group
Modality: PROTACs (E3 ligase recruitment) → Targeted Protein Degraders (TPDs) → Small Molecules, Bivalent/Multivalent Binders → Multivalent & Scaffold-Based Small Molecules → Small Molecules
Administration: Intravenous

Overview

SCR-9140 is a small molecule proteolysis-targeting chimera (PROTAC) designed to selectively degrade the SMARCA2 protein. Developed by Simcere Pharmaceutical Group (specifically its subsidiary Simcere Zaiming), the drug leverages the principle of synthetic lethality to target tumors with SMARCA4 deficiencies. SMARCA2 and SMARCA4 are paralog subunits of the BAF (SWI/SNF) chromatin remodeling complex; in cells where SMARCA4 is lost or mutated, they become dependent on SMARCA2 for survival. SCR-9140 has demonstrated potent antitumor activity in preclinical models of non-small cell lung cancer (NSCLC) and other SMARCA4-deficient cancers while maintaining a favorable safety profile in normal cells.

Targets

SMARCA2 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily A member 2)

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