sCSF-1RM149K-Fc

sCSF-1RM149K-Fc is a recombinant fusion protein designed as a high-affinity decoy receptor (trap) for the cytokines Colony Stimulating Factor-1 (CSF-1) and Interleukin-34 (IL-34). It consists of the extracellular domains (D1 to D5) of the human Colony Stimulating Factor-1 Receptor (CSF-1R) with a specific methionine-to-lysine mutation at position 149 (M149K), which significantly enhances its binding affinity for both ligands compared to the wild-type receptor. This mutated receptor fragment is dimerized using a silenced human IgG1 Fc sequence to improve stability and extend its half-life. By sequestering CSF-1 and IL-34, sCSF-1RM149K-Fc prevents their interaction with membrane-bound CSF-1R, thereby inhibiting the survival of monocytes and the differentiation of immunosuppressive tumor-associated macrophages (TAMs). Preclinical studies in pleural mesothelioma models have demonstrated its ability to restore cytotoxic T-cell responses and inhibit tumor growth, suggesting therapeutic potential in cancers driven by the CSF-1R pathway.

Other names

mutated soluble CSF-1R-FcsCSF-1R(M149K)-Fc