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SCT80A
- Development stage
- Unknown
- Lead developer
- Sinocelltech
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
SCT80A is a bispecific T-cell engager (BiTE) developed by Sinocelltech, designed to target both CD30 on tumor cells and CD3 on T cells. By simultaneously binding to these two antigens, the antibody facilitates the formation of an immunological synapse between cytotoxic T lymphocytes and CD30-expressing malignant cells. This interaction triggers T-cell activation and the release of perforins and granzymes, leading to the targeted lysis of the tumor cells. CD30 is a well-validated target in hematologic oncology, frequently overexpressed in Hodgkin lymphoma and anaplastic large cell lymphoma (ALCL). SCT80A is currently being investigated in clinical trials for the treatment of CD30-positive malignancies.
- Other names
- CD30xCD3 bispecific antibodyCD-30xCD3 bispecific antibodyCD 30xCD3 bispecific antibodyCD30×CD3双抗CD30×CD3 bispecific
02
Targets
CD3E (T-cell surface glycoprotein CD3 epsilon chain receptor)CD3 (T-cell surface glycoprotein CD3)CD30 (CD30 antigen)
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