scutellaria barbata extract

Scutellaria barbata extract, specifically the investigational botanical drug BZL101 (FDA IND# 59,521), is an aqueous extract derived from the aerial parts of the traditional Chinese medicinal herb *Scutellaria barbata* D. Don. The extract contains a complex mixture of bioactive flavonoids, including scutellarin, wogonin, baicalein, and luteolin. It exerts antineoplastic effects by inducing selective apoptosis in cancer cells and inhibiting tumor cell proliferation and angiogenesis. Its mechanism of action involves the modulation of multiple signaling pathways, including Hedgehog, Akt, and p53, as well as the upregulation of pro-apoptotic proteins such as Caspase-8 and TRAILR-1. Clinical development reached Phase 1 trials for metastatic breast cancer, demonstrating favorable safety and preliminary efficacy, but further development was halted due to funding constraints. Recent research also indicates potential therapeutic application in pancreatic, colorectal, prostate, and gynecological cancers.

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Other names

Ban Zhi LianScutellaria barbata D. Don extract